• Clomiphene is used to stimulate ovulation when a woman's ovaries can produce a follicle but hormonal stimulation is deficient. This medication is not recommended for women whose ovaries no longer make eggs properly.

How should you take this medication?

• Clomiphene must be taken by mouth exactly as directed by your doctor in order to be most effective.
• Do not take clomiphene without first talking to your doctor if you

• might be pregnant

• have a thyroid problem;

• have undiagnosed vaginal bleeding

• have uterine fibroids

• have liver disease
   

• If you miss a dose, take it as soon as you remember. If it is time for your next dose, take the 2 doses together and go back to your regular schedule.

General Precautions with clomiphene

• Before taking clomiphene, tell your doctor Tell your doctor if you have ever had any unusual or allergic reaction to clomiphene.
   
• Use caution when driving, operating machinery, or performing other hazardous activities. Clomiphene may cause blurred vision or other visual side effects during or shortly after therapy. Notify your doctor immediately if you develop any visual side effects and use caution when performing hazardous activities, especially under conditions of variable lighting.
   
• Clomiphene may increase the likelihood of multiple births. Multiple births may carry additional risk both for the mother and for the fetuses.

What are the possible side effects of clomiphene?

• Stop taking clomiphene and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).
• Stomach upset, bloating, abdominal discomfort, hot flashes, headache, or dizziness may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.
   
• The ovarian hyperstimulation syndrome has been reported to occur in patients receiving clomiphene. Symptoms of OHSS include swelling of the hands or legs, abdominal pain and swelling, shortness of breath, weight gain, and nausea or vomiting. Notify your doctor immediately or seek emergency medical attention if you develop any of these side effects.
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