Graves' disease is
a condition in which the thyroid gland makes too much
thyroid hormone
This is the most common type of excessive function of
the thyroid gland and it is five times more common in
females, with a peak occurring in adolescence.
The thyroid gland produces the thyroid hormones
triiodothryronine (T3) and thryroxine (T4). T3 is the
more active form. T4 is also partially converted to T3
when released in the blood stream.
Causes
Graves' disease results when the body's immune system
attacks the thyroid gland. The immune system normally
guards the body against infections and cancer by
making special proteins called antibodies. In Graves'
disease, the blood cells that perform this task
produce antibodies against proteins on the surface of
thyroid cells.
Symptoms
Generally, the symptoms of Graves' disease are
identical to the symptoms of hyperthyroidism, a
condition that can be caused by Graves' disease.
Signs and symptoms of Graves' disease may include:
- Shortness of breath
- Weakness
- Double vision
- Heat intolerance
- Muscle wasting
- Hair loss
- Infrequent or absent menstrual periods
- Weight loss
- Increased blood pressure
- Increased sweating
- Fatigue
- Moist, warm skin
- Thinning nails
Treatment
Currently there is no treatment available to stop
production of the antibodies that cause
hyperthyroidism. However, there are three courses of
treatment available to help Graves' disease patients
have more normal levels of thyroid hormone and to
control their symptoms. Anti-thyroid drugs are used to
decrease the production of thyroid hormone. Beta
blockers, which do not affect production of thyroid
hormone, are used to control symptoms.
Because of the failure of anti-thyroid drugs to cure the majority of
patients, physicians treat most patients with
radioactive iodine.
Surgical removal of most of the thyroid gland is the
other alternative for severe cases of Graves' disease.
As with any surgery there are risks and because there
are so many important structures in the area of the
thyroid gland, it becomes even riskier as more
complications could arise. After surgery you will need
to take thyroid hormones the rest of your life.