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Cold Sore

 

Definition

     Cold sore is caused by Herpesvirus which is sexually transmitted. The first lesion may have no symptoms. The lesions (vesicles, blisters, open sores) may occur up to two weeks after contact with someone who has the virus. The virus may become latent and live in the nerve cells to return at any time, causing Cold Sores in or near the same locale.  This occurs whenever the body is under stress (from illness, physical or emotional stress).

Cause

  • Herpes is caused either by Herpesvirus 1 or Herpesvirus 2. Both can affect the oral and genital areas, but Herpesvirus 1 exists predominately in the mouth, and Herpesvirus 2 in the genitals.

Symptoms

  • Small groups of blisters on top of a red base

  • Lesions appear near the mouth, on the lips, tongue, gums, and the nose.

  • There is tingling or burning before the blisters appear.

  • There is mild to moderate pain.

  • The blisters are fluid filled, and tend to ooze and crust.

  • Lesions last 7-10 days, and usually heal without any scarring.

  • During the acute period, the virus can be transmitted to others via direct contact.

  • Virus particles can be isolated from saliva for weeks after the blisters are gone.

Screening and Diagnostics

  • Tzanck smear

  • Immuno-fluorescent antibody slide

  • Viral culture

Treatment

  • Denavir ointment for Cold Sores

  • Oral acyclovir, Famvir, or Valtrex

Complications

  • In patients with AIDS (and rarely in those free of AIDS), Encephalitis (brain infection) may occur.

  • Theesophagus may be infected by Herpesvirus, causing an Esophagitis.

 
 

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