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Amenorrhea

 

 

Definition

 

     Amenorrhea is the absence of menstruation. It refers to missing periods in a female age 16 or older.

 

Causes

  • Imperforate hymen (the opening to the vagina is covered by skin)

  • Cervical stenosis (the cervix is closed)

  • Eating Disorders: sudden weight reduction, obesity, Anorexia Nervosa, fad dieting

  • Intense exercise

  • Stress

  • Malnutrition

  • Chronic disease, e.g., diabetes, anemia, congenital heart disease, thyroid disease

  • Pituitary or hypothalamic failure

  • Chromosomal anomaly, e.g., Turner's Syndrome

  • Congenital adrenal hyperplasia

  • Ovarian dysfunction

  • Absence or abnormality of one or more of the female reproductive organs

Symptoms

 

     No menstrual flow

 

Screening and Diagnostics

  • Physical examination and medical history

  • Urine pregnancy test

  • Progesterone withdrawal

  • Chromosome analysis

  • Serum chemistry (serum gonadotropin)

    • LH

    • FSH

    • Prolactin

    • TSH

    • T3 and T4

  • Urine chemistry, 17-ketosteroids

  • Head CT

  • Head MRI scan

  • Ultrasound, pelvic region

  • Laparoscopy

Treatment

  • Varies, depending on the cause, and may include:

    1. Hormonal replacement therapy and/or other medications

    2. Surgery minor and/or major

    3. Psychosocial counseling

    4. Long-term follow-up by an internist or other medical specialist

 
 

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